Myeloperoxidase is a glycoprotein that contains an alpha2 beta2 heteromultimer. It is found in all cells of myeloid lineage. MPO is found in abundance in the azurophilic granules polymorphonuclear neutrophils. MPO is an enzyme that aids in the phagocytic destruction of foreign particles. It also plays a role in the defense of the organism by producing hypochlorous acid, a powerful oxidant.
Activated polymorphonuclear neutrophils quickly release MPO. Multiple sclerosis, lung cancer, Alzheimer's, multiple sclerosis and atherosclerosis have all been linked to MPO. Wegeners disease is caused by autoimmune antibodies to MPO. MPO has received more clinical attention since its discovery. You can buy myeloperoxidase ELISA kit online.
Initially, MPO was considered rare and only available to patients with severe infections. Myeloperoxidase is a hemoprotein found in neutrophils. It is secreted during activation. Native Myeloperoxidase can be described as a covalently bound, tetrameric complex that includes two glycosylated Alpha chains with molecular weights ranging from 59 to 64 kDa.
Myeloperoxidase has been traditionally considered a target for anti-neutrophil cytoplasm antibody (ANCA), which are serological markers for systemic vasculitis like periarteritis, microscopic polyarteritis, and pulmonary eosinophilic granulomatosis. Rheumatoid-arthritis sufferers also have low to moderate levels of anti-myeloperoxidase self antibodies.
Recent research has shown that myeloperoxidase plays a role in the progression and initiation of cardiovascular disease. Myeloperoxidase has potent proinflammatory effects and could contribute to tissue injury. Myeloperoxidase has been identified as one of the best cardiac markers. Myeloperoxidase forms part of the host defense system for polymorphonuclear Leukocytes.